Serie A - Round 21 - Score Predictions & Best Bets

Pisa vs Atalanta

Pisa welcome Atalanta knowing they face one of the most dangerous attacking sides in the league. Atalanta’s intensity and depth should overwhelm the hosts, especially if the game opens up early.

Prediction: Pisa 1-3 Atalanta

Best Bet: Atalanta win + Over 2.5 goals

Udinese vs Inter

Inter travel to Udine looking to maintain pressure at the top of the table. Udinese can be stubborn at home, but Inter’s control and finishing quality should see them through.

Prediction: Udinese 0-2 Inter

Best Bet: Inter win + Clean sheet

Napoli vs Sassuolo

Napoli’s attacking rhythm has returned in recent weeks and Sassuolo’s defensive fragility could be exposed. Expect Napoli to dominate possession and chances.

Prediction: Napoli 3-1 Sassuolo

Best Bet: Napoli win + BTTS

Cagliari vs Juventus

Juventus head to Sardinia knowing efficiency is key in tight away fixtures. Cagliari will fight hard, but Juve’s defensive structure should be decisive.

Prediction: Cagliari 0-1 Juventus

Best Bet: Juventus win + Under 2.5 goals

Parma vs Genoa

A classic mid-table clash where margins will be slim. Parma’s home advantage gives them a slight edge, though Genoa are capable of frustrating their opponents.

Prediction: Parma 1-1 Genoa

Best Bet: Draw or BTTS

Bologna vs Fiorentina

Both sides are pushing for European spots and this fixture could prove pivotal. Expect an open game with chances at both ends.

Prediction: Bologna 2-2 Fiorentina

Best Bet: BTTS + Over 2.5 goals

Torino vs Roma

Roma face a difficult trip to Turin against a well-organised Torino side. Roma’s attacking quality may just tip the balance in a tightly contested match.

Prediction: Torino 1-2 Roma

Best Bet: Roma draw no bet + BTTS

Milan vs Lecce

Milan should control proceedings at San Siro against a Lecce side that struggles away from home. A professional performance is expected.

Prediction: Milan 2-0 Lecce

Best Bet: Milan win + Clean sheet

Cremonese vs Verona

A relegation battle where tension may outweigh quality. Both teams will be desperate not to lose, which could lead to a cautious affair.

Prediction: Cremonese 1-1 Verona

Best Bet: Under 2.5 goals

Lazio vs Como

Lazio will expect three points against a newly promoted Como side. If Lazio start strongly, the match could be decided early.

Prediction: Lazio 3-0 Como

Best Bet: Lazio win + Over 2.5 goals

Final Thoughts

Serie A Round 21 offers a strong mix of title pressure, European battles, and relegation clashes. Inter and Juventus will aim to grind out results on the road, while Napoli and Milan have favourable home fixtures. Lazio vs Como looks one-sided on paper, but Serie A rarely disappoints when it comes to drama.

Disclaimer: All Serie A score predictions and betting tips on this page are created by our editorial team after analysis of form, fixtures, and available data. Football is unpredictable, and readers should always make their own informed decisions. Bet responsibly.