Premier League - Round 22 - Score Predictions & Bets

Manchester United vs Manchester City

The Manchester Derby sees United host City at Old Trafford. Under new manager Michael Carrick, United will hope to fend off a resilient City side looking to renew momentum in the hopes of closing the gap with Arsenal. The game of the week will be the early kick-off on Saturday, opening the show for Matchweek 22.

Prediction: United 1-2 City

Best Bet: Haaland to score + Cherki to assist + Over 3 cards

Sunderland vs Crystal Palace

Hampered by missing players due to AFCON, Sunderland are winless in their last 5 games. However, they face off against a poor Palace side who have had a miserable run of form. A far cry from their early-season heroics, both sides will be eager to gain some momentum in the latter half of the season.

Prediction: Sunderland 1-0 Palace

Best Bet: Sunderland to keep a clean sheet + Roefs MOTM

Chelsea vs Brentford

Chelsea continue to search for consistency and face a well-drilled Brentford side that rarely makes things easy for top-half teams.

Prediction: Chelsea 2-1 Brentford

Best Bet: Chelsea win + Over 2.5 goals

Liverpool vs Burnley

Liverpool should dominate proceedings at Anfield against a Burnley side fighting for survival. Anything other than a comfortable home win would be a surprise.

Prediction: Liverpool 3-0 Burnley

Best Bet: Liverpool win + Clean sheet

Tottenham Hotspur vs West Ham United

A battle between two struggling London sides, as Spurs host West Ham. Thomas Frank is under increasing pressure to gain 3 points after a poor season so far. He must win 3 points if he wants to retain his job as West Ham look certain to go down to the Championship.

Prediction: Spurs 2-1 West Ham

Best Bet: Richarlison  to score + Over 2 cards + Romero to get booked

Leeds United vs Fulham

Daniel Farke’s unbeaten run came to an end last week, but he will hope to restart the momentum for his side. They host a brilliant as of late Fulham side who, like Brentford, are on red-hot form, going unbeaten in their last 5 games.

Prediction: Leeds 1-2 Fulham

Best Bet: Jimenez to score + BTTS

Nottingham Forest vs Arsenal

The league leaders travel to the Midlands on Saturday as they face off against Forest. This should be a relatively comfortable fixture for the Gunners, fresh off a thrilling victory against Chelsea in the Carabao Cup.

Prediction: Forest 0-2 Arsenal

Best Bet: Martinelli to score + Gabriel SOT + Over 8 corners

Wolverhampton Wanderers vs Newcastle United

A resurgent Wolves side host Newcastle on Sunday as they look to keep up somewhat of a comeback. They will need to be on form as they face off against a solid Newcastle side, but any point at home could be crucial to surmounting a seemingly impossible escape from relegation.

Prediction: Wolves 1-2 Newcastle

Best Bet: BTTS + Woltemade to score/assist

Aston Villa vs Everton

Unai Emery’s side will be desperate to get back to winning ways after a draw in their previous fixture. They should expect to edge out Everton at Fortress Villa Park. Everton have been far from their best as of late and look set to struggle against a formidable Aston Villa side.

Prediction: Villa 2-0 Everton

Best Bet: Rodgers to score/assist + Watkins to score/assist + Villa keep a clean sheet

Brighton & Hove Albion vs Bournemouth

Two sides that were previously high flying,m have fallen off quite a bit recently. Bournemouth will be reeling from the loss of star player Antoine Semenyo, following his transfer to Manchester City. Brighton will need to use their home advantage to gain 3 points in a critical Monday clash.

Prediction: Brighton 1-0 Bournemouth

Best Bet: Welbeck to score + Over 3 cards

Final Thoughts

Matchweek 22 features some crucial clashes from all ends of the table. Teams in relatively similar positions, such as Sunderland and Crystal Palace and Brighton and Bournemouth, will face off against each other in must-win clashes. Undoubtedly, the match of the week takes place Saturday lunchtime as Manchester United host Manchester City at Old Trafford. Be sure to tune in to a thrilling week of Premier League football!

Disclaimer: All Premier League score predictions and betting tips on this page are created by our editorial team after analysis of form, fixtures, and available data. Football is unpredictable, and readers should always make their own informed decisions. Bet responsibly. Clicking on the “Best Bet” text will redirect you to Bet365, where new customers can receive £30 in free bet credits when signing up. T&Cs apply. 👉 Check out the live odds for every Premier League match and follow us on Twitter for more updates!