Premier League - Round 21 - Score Predictions & Best Bets
- 365FootyTeam

- Jan 6
- 4 min read

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West Ham United vs Nottingham Forest
The Irons host Forest for the sole game on Tuesday, in what is expected to be a tight encounter. West Ham are fresh off a thrashing from last-place Wolves, a damning indictment of a terrible season which sees them firmly in the relegation zone.
Prediction: West Ham 0-2 Forest
Best Bet: Forest to keep a clean sheet + Over 3 cards
Bournemouth vs Tottenham Hotspur
Spurs travel to the South Coast on Wednesday to face off against Bournemouth. Spurs have been far from their best all season, but should expect to gain 3 points against an extremely poor Bournemouth side, who have slipped down to 15th in the table.
Prediction: Bournemouth 0-2 Spurs
Best Bet: Spurs to keep a clean sheet + Over 7 corners
Brentford vs Sunderland
On the flip side, Brentford vs Sunderland is a matchup between two high-flying sides, sitting 7th and 8th respectively. Brentford have won 3 out of their last 5 games, going unbeaten in that time, while Sunderland are also unbeaten in their last 5 games. This is a thrilling matchup between two outperforming sides.
Prediction: Brentford 1-1 Sunderland
Best Bet: Xhaka to get MOTM + Roefs over 3 saves
Crystal Palace vs Aston Villa
A once high-flying Palace side has slipped down to 14th place after a torrid run of form. They have lost 4 out of their last 5 fixtures and look set to continue that streak as they host Unai Emery’s Villa side on Wednesday. Villa go into the die the dominant side, only losing to league leaders Arsenal.
Prediction: Palace 0-2 Villa
Best Bet: Watkins to score/assist + Villa to keep a clean sheet
Everton vs Wolves
Everton host Wolves on Wednesday in what should be a comfortable game for the Toffees. Wolves have picked up their first win of the season, thrashing West Ham at Molineux, and they do look revitalised. However, it will be a challenge to gain a point over a resilient David Moyes’ side.
Prediction: Everton 2-1 Wolves
Best Bet: Over 4 cards + BTTS
Fulham vs Chelsea
The battle of West London will take place at Craven Cottage on Wednesday evening. Fulham are in great form, having 3 wins and 2 draws from their previous 5 fixtures. The same cannot be said for Chelsea, who have only picked up 1 win from 5; however, a thrilling last minute equlaiser against City may be the spark they need.
Prediction: Fulham 1-2 Chelsea
Best Bet: Palmer to assist + Reece James to get MOTM
Manchester City vs Brighton
Pep Guardiola will look to regain momentum after two consecutive disappointing draws. City should expect to pick up 3 points against Brighton, who are not in the best of form. They will need 3 points if they expect to challenge Arsenal for the title.
Prediction: City 3-1 Brighton
Best Bet: Haaland to score + Cherki to assist
Burnley vs Manchester United
Manchester United are without Amorim and will be with an interim manager as they travel to Burnley on Wednesday. Despite being without a manager, United should expect to gain 3points here as Burnley have been miserable all season.
Prediction: Burnley 0-2 Manchester United
Best Bet: United to keep a clean sheet + Bruno to get an assist
Newcastle United vs Leeds United
St James Park will host a resurgent Leeds side, who are unbeaten in their last 5 fixtures. Newcastle still go into the tie as favourites, having won their last two fixtures. Can Daniel Farke’s men hold off Eddie Howe’s side?
Prediction: Newcastle 2-1 Leeds
Best Bet: Woltemade to score + Over 8 corners
Arsenal vs Liverpool
Undoubtedly, the game of the week sees the Reds travel to the Emirates for the sole fixture on Thursday. Arsenal are flying at the top of the table as they are currently 6 points ahead of City and Aston Villa. The Reds have drawn their previous two fixtures but are still resurgent following an early-season slump. The game of the week promises fireworks!
Prediction: Arsenal 2-1 Liverpool
Best Bet: Wirtz to score/assist + Gabriel to score/assist
Final Thoughts
Matchweek 21 offers some tantalising fixtures in a classic midweek session for the Premier League. With the FA Cup in store during the weekend, teams will need to manage their squads in order to maximise results across both competitions. Undoubtedly, the best game of the week is Arsenal vs Liverpool on Thursday, while Brentford vs Sunderland is the battle of the overperformers. Be sure to tune in for a thrilling midweek session of football! Disclaimer: All Premier League score predictions and betting tips on this page are created by our editorial team after thorough research, analysis of past matches, and the latest available data. However, football is unpredictable, and we strongly recommend that readers make their own informed decisions before placing any bets. Bet responsibly.



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