La Liga - Round 21 - Score Predictions & Best Bets

Levante vs Elche

A relegation six-pointer kicks off the round as Levante host Elche. Both sides are desperate for points, but Levante’s home form could give them a narrow edge in a tense affair.

Prediction: Levante 2-1 Elche

Best Bet: Levante draw no bet + BTTS

Rayo Vallecano vs Osasuna

Rayo continue to punch above their weight this season and should fancy their chances at home. Osasuna remain solid but often struggle to control games away from El Sadar.

Prediction: Rayo Vallecano 1-0 Osasuna

Best Bet: Under 2.5 goals

Valencia vs Espanyol

Valencia are slowly stabilising after a turbulent campaign, while Espanyol remain inconsistent. Mestalla could prove decisive in what should be a tight encounter.

Prediction: Valencia 2-1 Espanyol

Best Bet: Valencia to win

Sevilla vs Athletic Club

A heavyweight clash sees Sevilla host Athletic Club in a battle for European places. Expect a physical, intense contest with chances at both ends.

Prediction: Sevilla 1-1 Athletic Club

Best Bet: Over 4 cards + Under 3.5 goals

Villarreal vs Real Madrid

One of the standout fixtures of the round. Villarreal are always tough at home, but Real Madrid’s quality and experience in big games should see them through.

Prediction: Villarreal 1-2 Real Madrid

Best Bet: Real Madrid win + BTTS

Atlético Madrid vs Mallorca

Atlético rarely slip up at home, especially against sides in the lower half. Mallorca will look to frustrate, but Simeone’s men should grind out a comfortable win.

Prediction: Atlético Madrid 2-0 Mallorca

Best Bet: Atlético win to nil

Barcelona vs Oviedo

Barcelona welcome Oviedo knowing anything less than three points would be a shock. Expect dominance from the hosts and a comfortable evening at Montjuïc.

Prediction: Barcelona 3-0 Oviedo

Best Bet: Barcelona -1.5 handicap

Real Sociedad vs Celta Vigo

Real Sociedad remain one of the most consistent sides in La Liga this season. Celta have quality but struggle defensively, especially away from home.

Prediction: Real Sociedad 2-1 Celta Vigo

Best Bet: Real Sociedad win

Alavés vs Real Betis

Monday night football sees Betis travel to Alavés in a tricky fixture. Betis’ technical quality should shine through, but it may not be straightforward.

Prediction: Alavés 1-2 Real Betis

Best Bet: Real Betis win or draw + BTTS

Girona vs Getafe

Girona have been one of the stories of the season and will look to continue their strong form at home. Getafe’s physical approach could make it scrappy.

Prediction: Girona 2-1 Getafe

Best Bet: Girona to win + Over 3 cards

Final Thoughts

La Liga Round 21 offers a strong mix of title implications, European battles, and relegation drama. Villarreal vs Real Madrid headlines the weekend, while Barcelona and Atlético Madrid will be expected to handle business at home. Girona continue to be must-watch as their incredible season rolls on.

Disclaimer: All La Liga score predictions and betting tips are based on form analysis and available data. Football is unpredictable, always bet responsibly and make informed decisions.